Balotelli scored his first goal for new club Brescia but the promoted northerners still fell to a 2-1 defeat to Napoli in Serie A action on Sunday.
The 29-year-old Italian international headed in after 67 minutes in his second match for his hometown club having missed four games because of a ban he incurred with former club Marseille.
First-half goals by Dries Mertens and Kostas Manolas ensured Napoli took all three points after their midweek loss to Cagliari, to boost confidence ahead of their Champions League trip to Belgian club Genk.
Carlo Ancelotti’s Napoli stays fourth with 12 points from six games, six behind league leaders Inter Milan who beat Sampdoria 3-1 on Saturday.
Inter have a maximum 18 points from six games — two ahead of Juve — after winning their first six league matches for the first time since the 1966-67 season.
Juventus beat SPAL 2-0 to stay second with Atalanta third — a point ahead of Napoli — after thrashing Sassuolo 4-1 on Saturday.
Balotelli carried his daughter Pia, who lives in Naples with her mother and was decked out in the Napoli colours, onto the pitch at the San Paolo Stadium.
The home side were without Senegalese defender Kalidou Koulibaly who has been given a two-match ban for his red card in the Cagliari game.